Tecnología

Who needs hard drives? Scientists store film clip in DNA

Who needs hard drives? Scientists store film clip in DNA”

What's a strand of DNA but data?

This doesn't mean you're going to be watching the latest season of "Game of Thrones" via your parakeet or whatever genetically modified pet you choose to store your video files on in the future, though it does technically make such a future possible.

CRISPR-short for Clustered, Regularly Interspaced, Short Palindromic Repeats-is a genetic phenomenon found in microbes that scientists adapted to disable a gene or add DNA at precise locations in the genetic code.

Eadweard Muybridge's image of galloping horse have been transferred into the DNA of living cells.

The team included researchers in the lab of Jennifer Doudna, one of the inventors of CRISPR-Cas9 gene editing, who determined how the anti-CRISPR protein binds to the CRISPR-Cas9 complex. Researchers then sequenced the genes of those cells and were able to reconstruct the image with 90 percent accuracy. Insights from this work suggest that AcrIIA4, and other natural inhibitor proteins, could help refine gene editing attempts based on CRIPSR and Cas enzymes, processes which have lacked a controllable "off-switch" to prevent undesired gene changes, to date. This was discovered by sequencing the whole genome of mice that had previously undergone CRISPR gene editing.

Coming soon to a petri dish near you-dramas that are as compelling as any that would reveal the mysteries of the human heart, only more intimate.

If a harmful mutation hit an important gene, such as a cancer-resisting 'tumour suppressor gene', it could cause unwanted health problems for users of Crispr.

Biologists from Harvard University in the US encoded in the DNA of Escherichia coli animation of the running horse designed by Edward Meybridzha in the nineteenth century.

The choice of image and video weren't random.

In her experiments on human cells in culture, Shin found that delivering CRISPR-Cas9 and then, several hours later, the anti-CRISPR protein, was the most effective way to reduce off-target effects.

The CRISPR/Cas system can be used to alter the nucleotide DNA sequence.

Anti-Crispr proteins stop Crispr-Cas9 from working, by mimicking DNA, and effectively tricking Crispr-Cas9 into binding with it, and then never letting go. Over the course of five days, they sequentially treated bacteria with frame after frame of translated DNA.

CRISPR-blocking proteins work by targeting a spot on the CRISPR-Cas9 molecule and binding with it, rendering the molecule unable to cut DNA, the team said. Meanwhile, neurons could be programmed to record how the brain develops in a living animal. Next, he and his team will try to show that they can record and decode information from the cell itself.

"We want to turn cells into historians", neuroscientist Seth Shipman, a post-doctoral fellow at Harvard Medical School in Boston, said in a news release. "We want to record information that we don't know", he told Spectrum.

"Last year we reported some success encoding a handful of sequence and getting some information back from it. But this time, we decide to encode real information rather than arbitrary sequences".

"We can use that to generate what we call molecular records, or recordings, into the genome of a living bacteria".



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